LIF, Murine

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Murine Leukemia Inhibitory FactorLIFLeukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF binds to the specific LIFR-α, which forms a heterodimer containing a GP130 signal transducing subunit.LIF is normally expressed in the trophectoderm of the developing embryo and has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte productionin vivo. While LIF is not required for human embryonic stem cell cultures, it is commonly used for mouse embryonic stem cell cultures.Sterile Filtered White lyophilized powderSource:Escherichia coliMW: ~19.9 kDa (180 amino acid) Purity: >98% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The specific activity determined by inducing differentiation of murine M1 myeloid leukemic cells. The minimum detectable concentration of rMuLIF in this assay is 0.5 ng/ml, corresponding to a specific activity of >2.0x106IU/mg.Store desiccated at -20°C.Mouse Genome Database:96787NOT FOR HUMAN USE!Cross-species homologyPercent SimilarityHuLIFMuLIFHuLIF***78.3MuLIF******