IFN-gamma, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Interferon GammaIFNGIFGIFN, Immune (IFI) Interferon gamma is the only type II interferon found in humans and binds to the heterodimeric IFNGR that consists of two chains, IFNGR1 and IFNGR2. This interaction activates the JAK-STAT pathway. IFNG is produced primarily by T-lymphocytes and natural killer (NK) cells. It is critical for innate and adaptive immunity against viral and intracellular bacterial infections. This is partly due to its ability to inhibit viral replication directly, but also due to its immunostimulatory and immunomodulatory effects. IFNG induces the production of cytokines and upregulates the expression of class I and II MHC antigens, Fc receptors, and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching, and potentiates the secretion of immunoglobulins by B cells. Additionally, IFNG augments TH1 cell expansion and may be required for TH1 cell differentiation.Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.Sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRGR RASQMW: ~16.9 kDa (144 amino acids) Purity: >98 % by SDS-PAGE and HPLC analyses.Biological Activity: Fully biologically active when compared to standard. The ED50as measured in anti-viral assay using human HeLa cells infected with encephalomyocarditis (EMC) virus is 0.15-0.80 ng/ml.Accession Number:P01579HGNC ID:5438Source:Escherichia coli