IL7, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Interleukin-7IL7Pre-B-cell growth factor (PBGF) Interleukin-7 (IL7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. It binds to the IL7 receptor, a heterodimer consisting of IL7 receptor alpha and IL2 receptor gamma chains. IL7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells. IL7 can also stimulate the proliferation of B-cells, T cells and NK cells (natural killer cells) . Murine IL7 has approximately 61% amino acid sequence identity with human IL7, and both proteins exhibit cross-species activity. IL7 has been examined as an immunotherapy agent in many human clinical trials for various malignancies, along with its role in HIV-positive individuals.Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.Sequence: DCDIEGKDGK QYESVLMVSI DQLLDSMKEI GSNCLNNEFN FFKRHICDAN KEGMFLFRAA RKLRQFLKMN STGDFDLHLL KVSEGTTILL NCTGQVKGRK PAALGEAQPT KSLEENKSLK EQKKLNDLCF LKRLLQEIKT CWNKILMGTK EHMW: ~17.4 kDa (152 amino acids) Purity: >97% by SDS-PAGE and HPLC analyses.Biological Activity: Fully biologically active when compared to standard. The ED50as determined by a cell proliferation assay using murine 2E8 cells is less than0.5 ng/ml, corresponding to a specific activity of >2.0 x 106IU/mg.Accession Number:P13232HGNC ID:6023Source:Escherichia coli