IL31, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Interleukin-31IL31Interleukin 31The human interleukin-31 (IL31) gene is located on chromosome 12, and is regulated so that IL31 is expressed in low levels in type 2 helper T-cells, which exist in the testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. IL31 shares several structural and functional characteristics with IL6, oncostatin M, leukemia inhibitory factor (LIF), and cardiotrophin-1. IL31 signals through the IL31 receptor A and oncostatin M receptor subunits. IL31 can also activate STAT3 through receptors and may be involved in skin immunity. Its use of regulating immune responses have been implicated in skin physiology and inflammatory skin diseases. IL31 may play a role in allergic diseases or disorders such as bronchial inflammation and asthma. Human IL31 shares 24% amino acid sequence homology with the mature mouse IL31.Sterile Filtered White Lyophilized Powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~15.8 kDa (141 amino acids) Purity: >97% by SDS-PAGE and HPLC analyses.