IL13, Rat (113 a.a.)

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Interleukin-13IL13Interleukin 13Interleukin-13 (IL13) is expressed by the IL13 gene and secreted by many cell types, especially helper T-cells type 2 (Th2) . The high solution form of IL13 is reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL13 in mice resulted in impaired Th2-cell development, and indicated an important role for IL13 in the expulsion of gastrointestinal parasites. IL13 exerts anti-inflammatory effects on monocytes and macrophages and inhibits the expression of inflammatory cytokines such as IL1β, TNF-α, IL6 and IL8. IL13 has also been shown to enhance B cell proliferation, and to induce isotype switching that results in an increased production of IgE. Mature rat IL13 shares 60%, 76%, and 60% amino acid sequence identity with human, mouse, and rhesus IL13, respectively.Sterile Filtered White Lyophilized Powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~12.3 kDa (113 amino acids) Purity: >98% by SDS-PAGE and HPLC analyses.