IL13, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Interleukin-13IL13Interleukin 13Human interleukin-13 (IL13) is expressed by the IL13 gene located on chromosome 5 and is secreted by many cell types, especially T-helper type 2 (Th2) cells. The high solution form of IL13 is reported to be a monomer with two internal disulfide bonds that contribute to a bundled four F-helix configuration. Targeted deletion of IL13 in mice resulted in impaired Th2 cell development and indicated an important role for IL13 in the expulsion of gastrointestinal parasites. IL13 exerts anti-inflammatory effects on monocytes and macrophages, and can also inhibit the expression of inflammatory cytokines such as IL1beta, TNF-alpha, IL6 and IL8. IL13 has also been shown to enhance B-cell proliferation, as well as induce isotype switching, which results in an increased production of IgE. Human, mouse and rat IL13 share a low percentage of homology, but have cross species activity.Sterile Filtered White Lyophilized Powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~12.5 kDa (112 amino acids) Purity: >97% by SDS-PAGE and HPLC analyses.