DEFB105A, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Defensin, Beta 105ADefensin, Beta 5, DEFB5, hBD-5Human beta-defensin 105A (DEFB105A) is an antimicrobial peptide that contributes to both the innate and the adaptive immune systems and is active against gram-negative and gram-positive bacteria, fungi, and viruses. Like the other β-defensins, DEFB105A is a small protein that contains a motif consisting of six cysteine residues which form three intramolecular disulfide bridges. It is expressed in the testis and epididymis. DEFB105A is a cationic peptide and interacts with the membranes of invading microbes, which are negatively charged due to the presence of lipopolysaccharides (LPS) or lipoteichoic acid (LTA) . LTA and LPS have higher affinity for DEFB103A than for Ca+2and Mg+2ions. The larger defensin molecule displaces the smaller ion, changing the membrane structure and affecting the stability of the membrane; this can lead to the formation of pores and subsequent depolarization or lysis. DEFB105A differs from the other β-defensins by consisting of 3 exons and 2 introns, instead of 2 exons and 1 intron.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~5.8 kDa (51 amino acids) Purity: >95% by SDS-PAGE and HPLC analyses.