CSF3 (G-CSF), Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Colony Stimulating Factor 3 (granulocyte) Granulocyte Colony-Stimulating Factor, G-CSFPluripoietinColony Stimulating Factor 3 (CSF3), formerly called granulocyte colony stimulating factor (G­CSF), is a pleiotropic cytokine. It is mainly produced by monocytes and macrophages upon activation by endotoxin, TNF­α and IFN­γ. Many cell types secreted this protein after LPS, IL1 or TNF­α activation, including fibroblasts, endothelial cells, astrocytes and bone marrow stromal cells. Various carcinoma cell lines and myeloblastic leukemia cells can express CSF3 constitutively. CSF3 is cytokine that acts in hematopoiesis by controlling the production, differentiation and function of two related white cell populations of the blood, the granulocytes and the monocytes­macrophages. In addition, it may function in some adhesion or recognition events at the cell surface.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW:~21.5 kDa (195 amino acids) Purity:>97% by SDS-PAGE and HPLC analyses.Biological Activity: Fully biologically active when compared to standard. The ED50determined by a cell proliferation assay using murine NFS-60 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x 107IU/mg.