CSF2 (GM-CSF), Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Colony Stimulating Factor 2 (granulocyte-macrophage) CSF2GM-CSFGMCSFMolgramostinMGI-1GM (Macrophage granulocyte inducer-1GM) Colony Stimulating Factor 2 (GM-CSF) was initially characterized as a growth factor that can support thein vitrocolony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts, in response to cytokine or immune and inflammatory stimuli. CSF2 is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic cells, CSF2 is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. It can induce human endothelial cells to migrate and proliferate and can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. CSF2 is species specific and human CSF2 has no biological effects on mouse cells.Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.Sequence: APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQEMW: ~14.6 kDa (128 amino acid) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The ED50as determined by a assay using human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0 x 107IU/mg.Accession Number:P04141HGNC ID:2434Source:Escherichia coli