CXCL6 (CXCL5), Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Chemokine (C-X-C motif) Ligand 5 (CXCL6) Recombinant Rat Chemokine (C-X-C motif) Ligand 5 (CXCL5) Lipopolysaccharide (LPS) Induced CXC Chemokine (LIX) Small Inducible Cytokine Subfamily B Member 5 (SCYB5) Murine Granulocyte Chemotactic Protein 2 (GCP2, GCP-2) Alveolar Macrophage Chemotactic Factor 2 (AMCF2, AMCF-2) Epithelial-derived Neutrophil Activating Peptide 78 (ENA78, ENA-78) Rat CXCL6 is an ELR type of CXC chemokine. It is expressed in various epithelial cell lines alongside CXCL8 (IL8) and CXCL1 in response to stimulation by IL1 or TNF-alpha. It is down regulated by IFNG. Rat CXCL6 is a ligand for Rat CXCR1. It is a chemoattractant and activator of neutrophils, and plays a role in angiogenesis and inflammation, as well as the metastasis of various cancers. It also blocks insulin signaling by activating the JAK2/STAT5/SOCS2 pathway. Rat CXCL6 has also been referred to as rat CXCL5 and is an ortholog of human CXCL5 and CXCL6, as well as murine CXCL5.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~10.1 kDa (93 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 10-100 ng/ml.