CXCL5 (70 a.a.), Murine

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Murine Chemokine (C-X-C motif) Ligand 5 (CXCL5) Epithelial-derived Neutrophil Activating Peptide 78 (ENA78, ENA-78) Lipopolysaccharide (LPS) Induced CXC Chemokine (LIX) Small Inducible Cytokine Subfamily B Member 5 (SCYB5) Murine Granulocyte Chemotactic Protein 2 (GCP2, GCP-2) Alveolar Macrophage Chemotactic Factor 2 (AMCF2, AMCF-2) Murine CXCL5 is an ELR type of CXC chemokine. It is expressed in various epithelial cell lines alongside CXCL8 (IL8) and CXCL1 in response to stimulation by IL1 or TNF-alpha. It is downregulated by IFNG. CXCL5 is a ligand for CXCR2 and CXCR1. It is a chemoattractant and activator of neutrophils, and plays a role in angiogenesis and inflammation, as well as the metastasis of various cancers. It also blocks insulin signaling by activating the JAK2/STAT5/SOCS2 pathway. Murine CXCL5 is an ortholog of human CXCL6 and is a more potent chemoattractant than human CXCL5 or CXCL6 on human neutrophils. The truncated forms of CXCL5 have been reported as being much more potent than the full length polypeptide.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.6 kDa (70 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 10-100 ng/ml.