CXCL3-beta, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Chemokine (C-X-C motif) Ligand 3, Beta (CXCL3β) Melanoma Growth Stimulating Activity, Gamma (MGSG, MGSA-g) Macrophage Inflammatory Protein 2 (MIP2-beta) Growth Related Oncogene 3 (GRO3, GRO-gamma) Cytokine Induced Neutrophil Chemoattractant 2, Beta (CINC-2B, CINC2B) Small Inducible Cytokine Subfamily B Member 3 (SCYB3) Dendritic Cell Inflammatory Protein 1 (DCIP1) Rat CXCL3 is an ELR type of CXC chemokine. It is secreted by monocytes and macrophages and expressed in a variety of other cells. As a result of alternative splicing, there are two isoforms of rat CXCL3 that differ from each other by three amino acid residues. This recombinant rat CXCL3 isoform is often referred to as CXCL3B or CINC2B. CXCR2 is the receptor that CXCL3 binds. CXCL3 participates in chemotaxis and cell activation of neutrophils. It plays a role in would healing, inflammation, angiogenesis, tumorigenesis, metastasis, and pathogenesis of airway remodeling in asthma. CXCL3 has an effect on the differentiation and function of monocyte-derived dendritic cells, pushing them towards a myeloid-derived suppressor cell (MDSC) -like phenotype.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.6 kDa (68 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected murine BaF3 cells is in a concentration range of 5-50 ng/ml.