CXCL3, Murine

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Murine Chemokine (C-X-C motif) Ligand 3Melanoma Growth Stimulating Activity, Gamma (MGSG, MGSA-g) Macrophage Inflammatory Protein 2 (MIP2-beta) Growth Related Oncogene 3 (GRO3, GRO-gamma) Cytokine Induced Neutrophil Chemoattractant 2, Beta (CINC2-beta) Small Inducible Cytokine Subfamily B Member 3 (SCYB3) Dendritic Cell Inflammatory Protein 1 (DCIP1) CXCL3 is an ELR type of CXC chemokine. It is secreted by monocytes and macrophages and expressed in a variety of other cells. CXCR2 is the receptor that CXCL3 binds. CXCL3 participates in chemotaxis and cell activation of neutrophils. It plays a role in would healing, inflammation, angiogenesis, tumorigenesis, metastasis, and pathogenesis of airway remodeling in asthma. CXCL3 has an effect on the differentiation and function of monocyte-derived dendritic cells, pushing them towards a myeloid-derived suppressor cell (MDSC) -like phenotype. CXCL3 exhibits antimicrobial activity against E. coli and S. aureus.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.9 kDa (73 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is in a concentration range of 10-100 ng/ml.