CXCL13, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Chemokine (C-X-C motif) Ligand 13 (CXCL13) B-Lymphocyte Chemoattractant (BLC) Small Inducible Cytokine Subfamily B Member 13 (SCYB13) Angie, Angie2B Cell-Attracting Chemokine 1 (BCA1) CXCL13 is a CXC chemokine lacking the ELR motif. It is expressed highest in liver tissue, followed by spleen, lymph nodes, appendix, and stomach. It is a ligand for CXCR5 and is selectively chemotactic for B lymphocytes. CXCL13 plays an essential role in the development of lymph nodes and the organization of B cells within lymphoid follicles, but its expression is downregulated within lymphoid tissues by IFN-gamma during immune responses. CXCL13 induces B cells to upregulate lymphotoxin alpha-1-beta-2, leading to CXCL13 expression and creating a positive feedback loop essential for follicular dendritic cell development and homeostasis.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~10.3 kDa (87 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human B cells is in a concentration range of 1-10 ng/ml.