CXCL12-gamma, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Chemokine (C-X-C motif) Ligand 12, Gamma (CXCL12γ) Stromal Cell-Derived Factor 1 (SDF1) Small Inducible Cytokine Subfamily B Member 12 (SCYB12) Pre-B Cell Growth-Stimulating Factor (PBSF) Thymic Lymphoma Cell-Stimulating Factor (TLSF) CXCL12 is a CXC chemokine lacking the ELR motif. CXCL12-gamma is mainly expressed in the heart, with weak expression being observed in several other tissues. CXCL12 acts as a ligand for CXCR4. It is chemotactic for human hematopoietic progenitor cells expressing CD34, mononuclear cells, and cerebellar granule cells. CXCL12 plays a role in lymphopoiesis, myelopoiesis, vascularization of the gastrointestinal tract, and cerebellar development. The mature form of CXCL12-gamma is targeted to the nucleolus of the cell. CXCL12-gamma is one of six alternatively spliced isoforms of the CXCL12 gene which all differ at the C-terminus.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~11.6 kDa (99 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 30-100 ng/ml.