CXCL12-alpha, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Chemokine (C-X-C motif) Ligand 12, Alpha (CXCL12α) Stromal Cell-Derived Factor 1 (SDF1) Small Inducible Cytokine Subfamily B Member 12 (SCYB12) Pre-B Cell Growth-Stimulating Factor (PBSF) Thymic Lymphoma Cell-Stimulating Factor (TLSF) Rat CXCL12 is a CXC chemokine lacking the ELR motif. It was first found in bone marrow stromal cells and is expressed in bone marrow stromal cells constitutively as well as a wide variety of cells with the exception of blood cells. Expression of CXCL12 is downregulated in fibroblasts by the phorbol ester TPA and in serum-deprived fibroblasts that have been stimulated by serum. CXCL12 acts as a ligand for CXCR4 and CXCR7. It is chemotactic for hematopoietic progenitor cells expressing CD34, mononuclear cells, and cerebellar granule cells. CXCL12 plays a role in lymphopoiesis, myelopoiesis, vascularization of the gastrointestinal tract, and cerebellar development. CXCL12-alpha is one of six alternatively spliced isoforms of the CXCL12 gene. It is four amino acids shorter at the C-terminus than the canonical sequence, CXCL12-beta.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.9 kDa (68 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.