CXCL12-alpha, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Chemokine (C-X-C motif) Ligand 12, Alpha (CXCL12α) Stromal Cell-Derived Factor 1 (SDF1) Small Inducible Cytokine Subfamily B Member 12 (SCYB12) Pre-B Cell Growth-Stimulating Factor (PBSF) Thymic Lymphoma Cell-Stimulating Factor (TLSF) CXCL12 is a CXC chemokine lacking the ELR motif. It was first found in bone marrow stromal cells and is expressed in a wide variety of cells with the exception blood cells. CXCL12 acts as a ligand for CXCR4. It is chemotactic for human hematopoietic progenitor cells expressing CD34, mononuclear cells, and cerebellar granule cells. CXCL12 plays a role in lymphopoiesis, myelopoiesis, vascularization of the gastrointestinal tract, and cerebellar development. CXCL12-alpha is one of six alternatively spliced isoforms of the CXCL12 gene. It is four amino acids shorter at the C-terminus than the canonical sequence, CXCL12-beta.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~8.0 kDa (68 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 20-80 ng/ml.