CCL8, Murine

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Chemokine (C-C motif) Ligand 8 (CCL8) Monocyte Chemoattractant Protein 2 (MCP2, MCP-2) Small Inducible Cytokine Subfamily A Member 8 (SCYA8) HC14Murine CCL8 is a chemokine containing four conserved cysteine residues, the first two of which are adjacent. It is expressed by peripheral blood leukocytes, as well as a variety of other cells. Expression of CCL8 is induced by IFNG, IFNB, IL1B, and various cytokine inducers such as viruses, endotoxins, and mitogens. It is chemotactic for monocytes, lymphocytes, basophils, and eosinophils and plays a role in tumor-associated leukocyte infiltration by recruiting leukocytes to sites of inflammation. CCL8 also inhibits CCR5-mediated HIV-1 entry and replication. CCL8 is a ligand for CCR1, CCR2B, CCR3, CCR5, CCR8, ACKR2, and ACKR4.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~8.5 kDa (74 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration of 10-100 ng/ml.