CCL5, Murine

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Murine Chemokine (C-C motif) Ligand 5 (CCL5) Regulated Upon Activation, Normally T-Expressed, and Presumably Secreted (RANTES) Small Inducible Cytokine Subfamily A Member 5 (SCYA5) T-Cell Specific Protein p228 (TCP228) Eosinophil Chemotactic Polypeptide 1 (EoCP1) Murine CCL5 is a chemokine containing four conserved cysteine residues, the first two of which are adjacent. It is expressed and secreted by T lymphocytes. Expression of CCL5 is induced by TNF-alpha and IL1-alpha and inhibited by stimulation of T lymphocytes. CCL5 is chemotactic for T lymphocytes, eosinophils, basophils, and monocytes and plays a role in recruiting these cells to inflammatory sites. It also induces proliferation and activation of CHAK cells and is an HSV and HIV-suppressive factor. CCL5 is a ligand for CCR1, CCR3, CCR5, and the viroreceptor M3. Murine CCL5 is chemotactic for both murine and human leukocytes in a dose-dependent fashion.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.9 kDa (68 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 1-10 ng/ml.