CCL3, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Chemokine (C-C motif) Ligand 3 (CCL3) Monocyte Chemoattractant Protein 1, Alpha (MCP1α, MCP-1α) Small Inducible Cytokine Subfamily A Member 3 (SCYA3) LD78-AlphaMacrophage Inflammatory Protein 1, Alpha (MIP1A) G0/G1 Switch Gene 19-1 (GOS-19-1) Rat CCL3 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed by T-cells, B-cells, macrophages, and various tumor cells lines and has been identified as a G0/G1 switch gene in various cells. CCL3 is the primary stimulator of TNF secretion and is chemotactic for polymorphonuclear leukocytes. CCL3 induces superoxide production by neutrophils, plays an inhibitory role in hematopoiesis, and displays inhibitory activity against strains of HIV-1, HIV-2, and SIV. CCL3 is a ligand for CCR1, CCR4, and the HIV-1 coreceptor CCR5. Activation of CCR5 through CCL3 activates a G-protein pathway through GNAI2 and a tyrosine phosphorylation through JAK2.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.9 kDa (69 amino acids) Purity: >98% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 10-100 ng/ml.