CCL22, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Chemokine (C-C motif) Ligand 22 (CCL22) Stimulated T Cell Chemotactic Protein 1 (STCP-1) Small Inducible Cytokine Subfamily A Member 22 (SCYA22) Macrophage-Derived Chemokine (MDC) Rat CCL22 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in activated splenic B-cells, macrophages, and dendritic cells. Expression of CCL22 is induced by IL4, IL13, and IFNG and inhibited by IL10. Increased expression CCL22 has also been observed after incubation of mast cells with TNF-alpha or IgE. CCL22 is chemotactic for chronically activated T-cells and plays a role in trafficking activated T cells. It also plays a role in migration and survival of cells expressing FOXP3. CCL22 is a ligand for CCR4.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.9 kDa (68 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 10-100 ng/ml.