CCL22, Murine

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Murine Chemokine (C-C motif) Ligand 22 (CCL22) Stimulated T Cell Chemotactic Protein 1 (STCP-1) Small Inducible Cytokine Subfamily A Member 22 (SCYA22) Macrophage-Derived Chemokine (MDC) Murine CCL22 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in activated splenic B-cells, macrophages, and dendritic cells. Expression of CCL22 is induced by IL4 and IL13 and inhibited by IL10. Increased expression of murine CCL22 has also been observed from bone marrow-derived mast cells after incubation with TNF-alpha or IgE. CCL22 is chemotactic for chronically activated T-cells and plays a role in trafficking activated T cells. It also plays a role in migration and survival of cells expressing FOXP3 in HTLV1 infection. CCL22 is a ligand for CCR4.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~7.8 kDa (68 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human activated lymphocytes is in a concentration of 10-100 ng/ml.