CCL2, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Chemokine (C-C motif) Ligand 2 (CCL2) Monocyte Chemoattractant Protein 1 (MCP1, MCP-1) Small Inducible Cytokine Subfamily A Member 2 (SCYA2) Monocyte Chemotactic Activating Factor (MCAF) Smooth Muscle Cell Chemotactic Factor (SMC-CF) Glioma-Derived Monocyte Chemotactic Factor (GDCF) CCL2 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cells, osteoblastic cells, and human pulmonary type 2-like epithelial cells. CCl2 expression is induced in peripheral blood mononuclear leukocytes by PHA, LPS, and IL1. It is chemotactic for monocytes and basophils and plays a role in recruiting macrophages and perpetuating inflammation in the joints of patients with rheumatoid arthritis. CCl2 is inhibited by insulin’s inhibitory effect on the activity of transcription factor NF-kappa-B. CCl2 is a ligand for CCR2 and CCR4.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~8.7 kDa (76 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 10-100 ng/ml.