CCL13, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Chemokine (C-C motif) Ligand 13 (CCL13) Moncyte Chemotactic Protein 4 (MCP4, MCP-4) Small Inducible Cytokine Subfamily A Member 13 (SCYA13) New CC Chemokine 1 (NCC1) Chemokine Beta 10 (CKB10) CCL13 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in epithelial cells and endothelial cells. Expression of CCL13 is induced by IL6 in primary synovial fibroblasts and activates the proliferation of rheumatoid synovial cells, contributing to the destruction of joints in rheumatoid arthritis. CCL13 is chemotactic for monocytes, T lymphocytes, and eosinophils. It stimulates histamine release from basophils and is a biomarker for asthma. CCL13 is a ligand for CCR2B, CCR3, and the viroceptor M3.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~8.6 kDa (75 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 10-100 ng/ml.