CCL11, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Chemokine (C-C motif) Ligand 11 (CCL11) Eotaxin, Eotaxin 1Small Inducible Cytokine Subfamily A Member 11 (SCYA11) Rat CCL11 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in fibroblasts, epithelial cells, smooth muscle cells, and dendritic cells. Expression of CCL11 is upregulated by several proinflammatory cytokines, including IL1A and TNFA, and is inhibited by IFNG. CCL11 is strongly and selectively chemotactic and activating for eosinophils and is involved in a variety of eosinophilic inflammatory diseases. It also plays a role in angiogenesis and tumor growth. CCL11 is a ligand primarily for CCR3, but also CCR1, CCR2, CCR5, and ACKR2 (D6) .Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~8.4 kDa (74 amino acids) Purity: >96% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration of 100-1000 ng/ml.