Cefotaxime (Sodium) 100 mg/mL Solution

Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. However, unlike many other cephalosporins, cefotaxime is not effective againstPseudomonas aeruginosabacteria. Cefotaxime is often used inAgrobacterium tumefaciens-mediated transformations to regulate bacterial growth. It has been shown to exhibit a synergistic effect with Vancomycin in certain conditions.Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.GoldBio’s antibiotic solutions are provided ready to use.Product Specifications:Cefotaxime Sodium in H2O (100 mg/mL Premade Solution, 0.2 µm Sterile Filtered) MOLECULAR BIOLOGY GRADEFormula: NaC16H16N5O7S2MW: 477.45 g/mol