Thiostrepton

Thiostrepton is a cyclic peptide antibiotic isolated fromStreptomyces azureus. It targets a wide variety of gram-negative and gram-positive bacteria, especially those causing skin infections. It has been used as a marker for selection of recombinantStreptomycescultures. Additionally, thiostrepton has been shown to inhibitFOXM1, a gene commonly overexpressed in cancer cell lines, thus inhibiting cancer cell growth.Thiostrepton functions by binding elongation factor G (EF-G) and interfering with ribosomal GTPase activity, ultimately inhibiting protein synthesis.Product SpecificationsThiostreptonMOLECULAR BIOLOGY GRADEFormula: C72H85N19O18S5MW: 1,664.89 g/mol