Dacarbazine

Dacarbazine (DTIC) is an anti-cancer prodrug that has been used as a standard for comparing the efficacy of new antineoplastic compounds. It is used with other anti-cancer compounds to both increase potency and disrupt side-effects generated by DTIC. While being a strong antineoplastic agent, DTIC has also been shown to stimulate interleukin 8 (IL8) and vascular endothelial growth factor (VEGF) expression in cancer cells.DTIC is transformed by liver enzymes into its active methyl diazonium cation form. The active form of DTIC has displayed anti-tumor activity following light exposure. It has been shown that the light exposure catalyzes methyl diazonium cation to form a carbine and aryl radical. These radicals damage DNA of malignant cancer cells, producing cytotoxic effects and eventual cell death.Product SpecificationsDacarbazineDTICFormula: C6H10N6OMW: 182.18 g/mol