Cryptotanshinone

Cryptotanshinone is a quinoid diterpene extracted fromSalvia miltiorrhiza Bungeand has been used as an antibacterial, anti-inflammatory and anti-cancer compound. As an antibacterial agent, cryptotanshinone exhibits a broad range of activity against gram positive bacteria.In vivostudies of bactericidal mechanisms have shown cryptotanshinone to form superoxides which damage bacterial proteins, lipids and DNA.Cryptotanshinone has also been used as an anti-inflammatory by inhibiting both nuclear factor-κB (NF-κB) activation and phosphorylation of mitogen-activated protein kinases (MAPK) . The anti-inflammatory actions occur in downstream pathways, inhibiting p38 MAPK, c-Jun N-terminal kinases (JNKs) and lipopolysaccharide induced inflammation. Inhibition of these pathways and molecules will decrease pro-inflammatory pathway responses as well as cytokine synthesis.As an anti-cancer agent, cryptotanshinone was used to inhibit cancer cell proliferation through the decreased expression of cyclin D1 or increase in cyclin A1 and cyclin B1 expression. It was also used to impede cancer motility by inhibiting complement component 5a protein (C5a), an analphylatoxin. Cryptotanshinone has also been used to reduce cell motility by inhibiting basic fibroblast growth factor (bFGF), a promoter of angiogenesis. Apoptotic effects were also observed by cryptotanshinone when it was used to inhibit signal transducer and activator of transcription-3 expression, which upregulates cell survival pathways.Product SpecificationsCryptotanshinoneTanshinone CFormula: C19H20O3MW: 296.36 g/mol