Camptothecin (Mappia foetida)

Camptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complexin vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.Camptothecin is found inMappia foetida (Nothapodytes foetida), a plant native to eastern India. The compound itself is produced by an endosymbioticAscomycota (Phycomycete) fungi.Camptothecin (Camptotheca acuminata), (GoldBio Catalog # C-705) has also been produced by endosymbiotic fungi present inCamptotheca acuminata, which is a tree predominantly found in southern China.Product SpecificationsCamptothecin (Mappia foetida) Formula: C20H16N2O4MW: 348.35 g/mol