8-Hydroxyquinoline

8-Hydroxyquinoline is an organic compound that is used as a RNA inhibitor, anti-cancer agent and bidentate chelating agent.In vitrostudies againstEscherichia colihad shown 8-hydroxyquinoline inhibiting RNA polymerase activity. The enzyme’s activity was inhibited by chelating manganese, magnesium or zinc cofactors. Activity of 8-hydroxyquinoline toward RNA polymerase is broad and inhibits the synthesis of vertebrate RNA as well as proteins.8-Hydroxyquinoline has also been used as an immobile chelating agent to remove transition metals, alkali and alkaline cations from solutions or within organisms. Its capability to bind the positively charged metals has been shownin vivoto inhibit proteasome activity in tumor cells by transporting copper ions into malignant cells. Halting proteasome activity was observedin vitroandin vivowith decreased cancer growth due to apoptosis.Product Specifications8-HydroxyquinolineFormula: C9H7NOMW: 145.16 g/mol