PRAS40 Rabbit mAb
This is a PRAS40 Rabbit mAb Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
PRAS40 interacts with Raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183.
Synonyms
40 kDa proline rich AKT substrate; AKT1 S1; AKT1 substrate 1 (proline rich) ; AKT1S1; Lobe; PRAS40; Proline rich akt substrate
Swiss Prot
Q96B36
Reactivity
Human, Mouse
Immunogen
A synthesized peptide derived from human PRAS40
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Recombinant Antibody
Applications
WB, IHC, IP, FC
Purification Method
Affinity purification
Assay Type
Antibody
Dilution
WB 1:500-1:2000, IHC 1:50-1:200, IP 1:50, FC 1:50
Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
40kDa
Host or Source
Rabbit
Isotype
IgG
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