IRF3 (Phospho-Ser386) Rabbit mAb
This is a IRF3 (Phospho-Ser386) Rabbit mAb Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE.
Synonyms
IRF3; Interferon regulatory factor 3
Swiss Prot
Q14653
Reactivity
Human
Immunogen
A synthesized peptide derived from human Phospho-IRF3 (S386)
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Recombinant Antibody
Applications
WB, ICC/IF
Purification Method
Affinity purification
Assay Type
Antibody
Dilution
WB 1:1000-1:2000, ICC/IF 1:50-1:200
Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
47kDa
Host or Source
Rabbit
Isotype
IgG
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