Arrestin 1 (Phospho-Ser412) Antibody

This is a Arrestin 1 (Phospho-Ser412) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.

Product Specifications

Background

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Synonyms

ARR1; arrestin 2; arrestin beta 1; beta-arrestin-1

Gene ID

408

Swiss Prot

P49407

Reactivity

Human

Immunogen

Peptide sequence around phosphorylation site of Serine 412 (T-G-S (p) -P-Q) derived from Human Arrestin 1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Phospho-Specific Antibody

Applications

WB, IHC

Purification Method

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.