Caspase 9 (Phospho-Thr125) Antibody

This is a Caspase 9 (Phospho-Thr125) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.

Product Specifications

Background

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Synonyms

APAF-3; MCH6; RNCASP9; CASP-9; ICE-LAP6

Gene ID

842

Swiss Prot

P55211

Reactivity

Human

Immunogen

Peptide sequence around phosphorylation site of threonine 125 (P-E-T (p) -P-R) derived from Human Caspase 9.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Phospho-Specific Antibody

Applications

WB, IHC

Purification Method

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.