Bub3 (Phospho-Tyr207) Antibody

This is a Bub3 (Phospho-Tyr207) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.

Product Specifications

Background

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

Synonyms

Mitotic checkpoint protein BUB3; Hbub3; BUB3L; BUB3 budding uninhibited by benzimidazoles 3 homolog; budding uninhibited by benomyl

Gene ID

9184

Swiss Prot

O43684

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence around phosphorylation site of Tyrosine 207 (V-E-Y (p) -L-D) derived from Human Bub3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Phospho-Specific Antibody

Applications

Purification Method

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.