C-Cbl (phospho-Tyr700) Antibody
This is a c-Cbl (phospho-Tyr700) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
Synonyms
Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55
Gene ID
867
Swiss Prot
P22681
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 770 (T-E-Y (p) -M-T) derived from Human c-Cbl.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Phospho-Specific Antibody
Applications
WB, IHC, IF
Purification Method
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Assay Type
Antibody
Concentration
1.0 mg/mL
Dilution
WB 1:500-1:1000, IHC 1:50-1:100, IF 1:100-1:200
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV722260 1.0 µg DNA
CYP4F45P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)
Sign In for Pricing
View Details 
MBS2088809-01 5x 96 Tests
Human Hypoxia Inducible Factor 1 Alpha (HIF1a) ELISA Kit DIY Materials
Sign In for Pricing
View Details MBS2088809-02 5x 96 Tests + MBS2089471 (Support Pack 1,5x 96 Tests)
Human Hypoxia Inducible Factor 1 Alpha (HIF1a) ELISA Kit DIY Materials
Sign In for Pricing
View Details MBS2088809-03 10x 96 Tests
Human Hypoxia Inducible Factor 1 Alpha (HIF1a) ELISA Kit DIY Materials
Sign In for Pricing
View Details