P53 (Phospho-Ser6) Antibody

This is a p53 (Phospho-Ser6) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.

Product Specifications

Background

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Synonyms

Antigen NY-CO-13 Phosphoprotein p53 Tumor suppressor p53; Cellular tumor antigen p53; TP53

Gene ID

7157

Swiss Prot

P04637

Reactivity

Human

Immunogen

Peptide sequence around phosphorylation site of serine 6 (P-Q-S (p) -D-P) derived from Human p53.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Phospho-Specific Antibody

Applications

WB, IHC

Purification Method

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.