Smad2 Monoclonal Antibody
This is a Smad2 Monoclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Synonyms
HMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2
Gene ID
4087
Swiss Prot
Q15796
Reactivity
Human
Immunogen
Purified recombinant human SMAD2 protein fragments expressed in E.coli.
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Monoclonal
Applications
WB, ICC
Assay Type
Antibody
Dilution
WB 1:500, ICC 1:100
Buffer
Ascites
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Observed Molecular Weight
60kDa
Host or Source
Mouse
Isotype
IgG1
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