Oleuropein

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

Product Specifications

CAS Number

[32619-42-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Cytochrome P450; PPAR

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/oleuropein.html

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : ≥ 20 mg/mL

Smiles

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@@H]2OC=C(C(OC)=O)[C@@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=C\C)([H])O1

Molecular Formula

C25H32O13

Molecular Weight

540.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9 (1) :376.|[2]Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19 (3) . pii: E686.