Piperonyl butoxide-d9

Piperonyl butoxide-d9 is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice[1][2][3][4].

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Muguruma M, et al. Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice. Arch Toxicol. 2008 Oct;82(10):749-53.|[3]Tanaka T, et al. Effects of piperonyl butoxide on exploratory behaviour in female mice. Toxicol Ind Health. 2019 Apr;35(4):314-323.|[4]Takahashi O, et al. Chronic toxicity studies of piperonyl butoxide in CD-1 mice: induction of hepatocellular carcinoma. Toxicology. 1997 Dec 26;124(2):95-103.