ZL-12A probe

ZL-12A probe is a "stereoprobe "that can promote the degradation of TFIIH helicase ERCC3. ZL-12A degrades ERCC3 by covalently modifying C342[1].

Product Specifications

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/zl-12a-probe.html

Purity

99.71

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N1C[C@H](C2(C1)CN(C2)C(C3=CC=C4NC=CC4=C3)=O)C5=CC=CC=C5)C=C

Molecular Formula

C24H23N3O2

Molecular Weight

385.46

References & Citations

[1]Liu Z, et al. Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. J Am Chem Soc. 2024 Apr 17;146 (15) :10393-10406.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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