ZL-12A probe
ZL-12A probe is a "stereoprobe "that can promote the degradation of TFIIH helicase ERCC3. ZL-12A degrades ERCC3 by covalently modifying C342[1].
Product Specifications
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/zl-12a-probe.html
Purity
99.71
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](C2(C1)CN(C2)C(C3=CC=C4NC=CC4=C3)=O)C5=CC=CC=C5)C=C
Molecular Formula
C24H23N3O2
Molecular Weight
385.46
References & Citations
[1]Liu Z, et al. Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. J Am Chem Soc. 2024 Apr 17;146 (15) :10393-10406.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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