BTB-1

BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM.

Product Specifications

CAS Number

[86030-08-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Kinesin; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BTB-1.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1=CC=C(Cl)C=C1[N+]([O-])=O)(C2=CC=CC=C2)=O

Molecular Formula

C12H8ClNO4S

Molecular Weight

297.71

Precautions

H302, H315, H319, H335

References & Citations

[1]Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48 (48) :9072-6.|[2]Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10 (2) :554-60.