Sob-AM2

Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ) . In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice[1].

Product Specifications

CAS Number

[2128258-47-7]

UNSPSC

12352005

Target

FAAH; Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sob-am2.html

Purity

98.5

Solubility

DMSO : 20 mg/mL (ultrasonic;warming)

Smiles

O=C(COC1=CC(C)=C(CC2=CC=C(C(C(C)C)=C2)O)C(C)=C1)NC

Molecular Formula

C21H27NO3

Molecular Weight

341.44

References & Citations

[1]Meinig J M, et al. Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy[J]. ACS chemical neuroscience, 2017, 8 (11) : 2468-2476.