L-Arginine-13C6, d14 (hydrochloride)

L-Arginine-13C6, d14 hydrochloride ((S) - (+) -Arginine-13C6, d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with 13C6. L-Arginine hydrochloride ((S) - (+) -Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator[1][2][3][4][5].

Product Specifications

Product Name Alternative

(S) - (+) -Arginine-13C6, d14 (hydrochloride)

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

[2H][13C]([2H])(N([2H])/[13C](N([2H])[2H])=N/[2H])[13C]([2H])([2H])[13C]([2H])([2H])[13C@]([2H])(N([2H])[2H])[13C](O[2H])=O.Cl

Molecular Formula

13C6HD14ClN4O2

Molecular Weight

230.70

References & Citations

[1]Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002) . Crit Care Med. 2004 Jan;32 (1) :1-12.|[2]Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56 (9) :439-45.|[3]Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20 (4) :709-17.|[4]Mizunuma T, et al. Effects of injecting excess arginine on rat pancreas. J Nutr. 1984 Mar;114 (3) :467-71.|[5]Siriviriyakul P, et al. Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine induced acute pancreatitis in mice. Heliyon. 2019 Aug 27;5 (8) :e02222.