TH34
TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].
Product Specifications
CAS Number
[2196203-96-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/th34.html
Purity
99.52
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(NO)C1=CC=C(C)C(NCC2=CC=CC=C2)=C1
Molecular Formula
C15H16N2O2
Molecular Weight
256.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92 (8) :2649-2664.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC10; HDAC6; HDAC8
Available Sizes
Curated Selection
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