OX04528

OX04528 (compound 68) is a potent, G-protein biased, and orally active GPR84 agonist. OX04528 no cytotoxicity. OX04528 inhibits cAMP production with an EC50 value of 0.00598 nM[1].

Product Specifications

CAS Number

[3028055-45-7]

UNSPSC

12352005

Target

GPR84

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ox04528.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[O-][N+]1=CC(CCCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=CC(O)=C1

Molecular Formula

C16H13F6NO2

Molecular Weight

365.27

References & Citations

[1]Wang P, et al. Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists. J Med Chem. 2024 Jan 11;67 (1) :110-137.