Edoxaban-d6
Edoxaban-d6 is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment[1][2][3].
Product Specifications
CAS Number
[1304701-57-2]
Product Name Alternative
DU-176-d6
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319
Target
Factor Xa; Thrombin
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.6
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=C(CN(CC2)C)S1)N[C@H]3[C@H](CC[C@@H](C3)C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)NC(C(NC4=CC=C(C=N4)Cl)=O)=O
Molecular Formula
C24H24D6ClN7O4S
Molecular Weight
554.09
Precautions
H302+H312+H332, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10264S/Edoxaban-d6-SDS-MedChemExpress.pdf
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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