PPARA antibody
Product Specifications
Background
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Synonyms
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) |Nuclear receptor subfamily 1 group C member 1|PPARA|NR1C1|PPAR
Gene ID
5465
UniProt
Q07869
Host
Mouse
Reactivity
Human, Rat
Immunogen
Peroxisome proliferator-activated receptor alpha
Target
PPARA
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
52-55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
11H4
Tested Applications
ELISA, WB
Immunogen Sequence
1-250aa
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